降氟除氟技术措施推广应用示范研究效果评估

目的 了解示范村降氟除氟技术措施实施效果,为降氟除氟技术措施的推广应用提供科学依据.方法 对6个示范村降氟除氟技术设施的质量抽查,检查8～12岁儿童氟斑牙、成人氟骨症病情、检测空气氟和尿氟,测试居民和儿童地氟病防治知识知晓情况.结果 6个示范村炉灶改造落实率为96.76%.炉改造合格率为97.00%,炉正确使用率为98.00%;灶改造合格率为97.70%、灶正确使用率为96.70%.儿童氟斑牙检出率为67.00%,缺损率为10.40%,氟斑牙指数为1.49;成人氟骨症无变化.居民与学生地氟病防治知识知晓率分别为86.40%、96.90%.空气氟旺火期0.005 9 mg/m<'3>,封火期0.002 8 mg/m<'3>.尿氟检测306份,中位数为0.69 mg/L.结论 在课题实施3年后,示范村炉灶落实率、炉灶合格率、炉灶正确使用率显著提高,降氟除氟技术措施实施达到预期效果.     

基于支持向量机的环境γ剂量率模型

核电厂外围环境辐射连续监测系统获取地表γ剂量率,当剂量率超过预先规定的阈值时,系统会发出警告。但氡子体影响、系统噪声造成的数值不稳定、剂量率具有周期性的变化均会使数据出现波动从而造成无效的报警。为辨别剂量率上升的原因,建立了支持向量机模型对环境剂量率超过阈值的原因进行分类,考察了不同参数对模型精度的影响。通过2000组以上历史数据验证,结果表明,该模型能对环境γ剂量率超过阈值的原因进行准确分类,准确率达98%以上。     

超长年限服役后铸铁烘缸的组织和性能

研究了某造纸厂2台分别服役62 a和43 a的铸铁烘缸不同位置的显微组织和力学性能。结果表明:2台烘缸缸体及端盖均无明显的表面缺陷和裂纹缺陷,基体组织均为无明显球化的珠光体,石墨片的尺寸和分布均主要为A型,服役62 a烘缸前端盖和服役43 a烘缸后端盖的石墨片长度均较长;2台烘缸缸体和端盖的硬度均满足标准要求;除服役62 a烘缸前端盖的抗拉强度低于标准外,2台烘缸其余位置的抗拉强度均满足标准要求,服役62 a烘缸前端盖和服役43 a烘缸后端盖的抗拉强度明显较其他位置的低;2台超长年限服役烘缸在0.22 MPa的最高工作内压载荷下仍具有足够的强度。     

轮腿式自动引导小车结构设计与行走步态规划

为了提高自动引导小车在存有障碍物的硬质平坦地面上的工作能力,设计了 一种新型的轮腿式自动引导小车,并阐述了小车在不同运动模式下的工作原理.对行走模式下的小车进行了运动学分析,得到足端工作空间.以足端的最大工作范围为前提规划了足端的运动轨迹,同时规划了车体的运动轨迹,并基于静态稳定裕度原理规划了小车整体的行走步态.利用ADAMS软件对该小车进行运动仿真分析,仿真结果表明所规划运动轨迹和行走步态是可行的.     

省级电网公司投资管理一体化信息平台构架及解决方案

随着"五大"体系建设的深入推进,由于缺乏相应的执行管控体系和信息化支撑手段,当前省级电网公司投资管理工作已不能满足提升投资管理精益化的要求。从信息化系统建设角度,分析了省级电网公司投资管理信息化支撑存在的问题,提出了"投资管理一体化信息平台"的总体构架,从总体系统应用架构、总体系统集成和总体技术路线3个方面,设计了技术解决方案,并基于ERP信息系统,实现了该信息平台的应用开发。     

Preparation and characterization of methoxy‐poly(ethylene glycol) side chain grafted onto chitosan as a wound dressing film

Chitosan has received extensive attention as a biomedical material; however, the poor solubility of chitosan is the major limiting factor in its utilization. In this study, chitosan‐based biomaterials with improved aqueous solubility were synthesized. Two molecular weights (750 Da and 2000 Da) of methoxypoly(ethylene glycol) (mPEG) were grafted onto chitosan (mPEG‐g‐chitosan) to form a ～100‐μm‐thick plastic film as a wound dressing. The chemical structures of the mPEG‐g‐chitosan copolymers were confirmed using Fourier transform infrared spectroscopy (FTIR), and the thermal properties were characterized using thermogravimetry analysis (TGA). Their microstructures were observed using scanning electron microscopy (SEM). The other properties were analyzed via the swelling ratio, tensile strength, elongation, and water vapor transmission rate (WVTR). Biocompatibility evaluations through biodegradability, cytotoxicity, and antimicrobial effect studies were also performed. The obtained mPEG‐g‐chitosan copolymers were soluble in slightly acidic aqueous solutions (pH～6.5) at a concentration of 10 wt %. The optimal mPEG‐g‐chitosan hydrogels had swelling ratios greater than 100% and WVTRs greater than 2000 g/m²/day. Their performance against Staphylococcus aureus will be subjected to further improvements with respect to medical applications. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42340.     

干式变压器的可视化检测研究

本文中作者提出了利用X射线DR检测系统对干式变压器内部缺陷进行透视检测的方法,检测出其绝缘介质内部裂纹,并通过仿真分析确认了该裂纹是造成其局部放电信号超标的原因。     

Upregulation of TLRs and IL-6 as a Marker in Human Colorectal Cancer

Toll-like receptors (TLRs) not only form an important part of the innate immune system but also serve to activate the adaptive immune system in response to cancer. Real-time PCR; immunohistochemical stain and Western blotting analyses were performed to clarify molecular alterations in colorectal cancer (CRC) patients. We identified Toll-like receptor 1 (TLR1), TLR2, TLR4 and TLR8 gene expression levels and downstream gene, i.e., interleukin-6 (IL-6), IL-8, interferon-α (IFN-α) and myeloid differentiation primary-response protein-88 (MyD88), expression levels in CRC patients and in cancer cell lines. CRC tissues have higher TLR1, TLR2, TLR4, TLR8, IL-6 and IL-8 gene expression levels than do the normal colon mucosa (p < 0.05). TLR2 expression varied in different cell types (mucosa and lymphocytes). There was no difference in the MyD88 and IFN-α gene expression levels between cancerous and normal colon mucosa. CRC patients had higher levels of IL-6 (p = 0.002) and IL-8 (p = 0.038) expression than healthy volunteers did; and higher IL-6 and IL-8 expression was also found to signify a higher risk of recurrence. CL075 (3M002) treatments can reduce the production of IL-8 in different cancer cell lines. The signaling pathway of TLRs in cancer tissue is different from that in normal cells; and is MyD88-independent. Higher expression levels of TLR1, TLR2, TLR 4 and TLR 8 mRNA were related to upregulation inflammatory cytokines IL-6 and IL-8 gene expression in tissue and to the upregulation of IL-6 in blood. The concentration of IL-6 in serum can be used as an indicator of the possibility of CRC recurrence. Treatment with 3M002 can reduce IL-6 production in vitro and may prevent CRC recurrence. Our findings provide evidence that TLR1, TLR2, TLR4 and TLR8 gene expression induce downstream IL-6 and IL-8 gene expression; detection of these expression levels can serve as a CRC marker.     

New Coumarin Derivatives and Other Constituents from the Stem Bark of Zanthoxylum avicennae: Effects on Neutrophil Pro-Inflammatory Responses

Three new coumarin derivatives, 8-formylalloxanthoxyletin (1), avicennone (2), and (Z)-avicennone (3), have been isolated from the stem bark of Zanthoxylum avicennae (Z. avicennae), together with 15 known compounds (4–18). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4, 9, 12, and 15 exhibited inhibition (half maximal inhibitory concentration (IC₅₀) values ≤7.65 µg/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 1, 2, 4, 8 and 9 inhibited fMLP/CB-induced elastase release with IC₅₀ values ≤8.17 µg/mL. This investigation reveals bioactive isolates (especially 1, 2, 4, 8, 9, 12 and 15) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.